Chuanzhu Yan Selected Research

Mitochondrial encephalopathy

1/2022	Bezafibrate Rescues Mitochondrial Encephalopathy in Mice via Induction of Daily Torpor and Hypometabolic State.
1/2020	Mitochondrial encephalopathy Due to a Novel Pathogenic Mitochondrial tRNAGln m.4349C>T Variant.
3/2014	MERRF/MELAS overlap syndrome due to the m.3291T>C mutation.

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Chuanzhu Yan Research Topics

Disease

14	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 03/2014
8	Muscular Diseases (Myopathy) 01/2022 - 10/2012
6	MELAS Syndrome (Syndrome, MELAS) 01/2022 - 06/2002
5	Stroke (Strokes) 01/2022 - 03/2014
5	Muscle Weakness 01/2022 - 02/2010
4	Atrophy 06/2022 - 01/2016
4	Dermatomyositis (Dermatopolymyositis) 05/2021 - 08/2015
4	Mitochondrial Myopathies (Mitochondrial Myopathy) 01/2021 - 07/2015
3	Lactic Acidosis 01/2022 - 03/2014
3	Mitochondrial encephalopathy 01/2022 - 03/2014
3	Inflammation (Inflammations) 01/2022 - 01/2011
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 01/2016
3	Atherosclerosis 12/2021 - 09/2015
3	Myositis (Idiopathic Inflammatory Myopathies) 05/2021 - 06/2015
3	MERRF Syndrome (Myoclonic Epilepsy and Ragged Red Fibers) 11/2020 - 06/2002
3	Brain Diseases (Brain Disorder) 01/2020 - 02/2010
2	Ataxia (Dyssynergia) 11/2022 - 04/2018
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 11/2020
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022 - 07/2016
2	Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy) 01/2022 - 06/2002
2	Type 2G Limb-Girdle Muscular Dystrophy 01/2022 - 01/2021
2	Dysferlinopathy 12/2021 - 06/2016
2	Myoclonus (Nocturnal Myoclonus) 11/2020 - 03/2014
2	Cerebellar Ataxia (Dysmetria) 11/2020 - 03/2014
2	Neutral Lipid Storage Disease with Myopathy 10/2019 - 10/2012
2	Glycogen Storage Disease Type II (Pompe's Disease) 01/2019 - 01/2016
2	Polymyositis 07/2016 - 06/2015
2	Vomiting 06/2015 - 03/2014
2	Parkinson Disease (Parkinson's Disease) 01/2015 - 01/2011
2	Multiple Acyl Coenzyme A Dehydrogenase Deficiency 05/2014 - 02/2010
2	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 03/2014 - 06/2002
1	Muscle Cramp (Cramp) 10/2022
1	Isaacs Syndrome (Neuromyotonia) 10/2022
1	Rare Diseases (Rare Disease) 10/2022
1	Ganglion Cysts (Ganglion) 09/2022
1	Hereditary Myopathy with Early Respiratory Failure 05/2022
1	Tremor (Tremors) 01/2022
1	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 01/2022
1	Nemaline Myopathies (Nemaline Myopathy) 01/2022
1	Neointima 12/2021
1	Atherosclerotic Plaque (Atheroma) 12/2021
1	Chronic Disease (Chronic Diseases) 12/2021
1	Pathologic Processes 12/2021
1	Muscular Dystrophies (Muscular Dystrophy) 01/2021

Drug/Important Bio-Agent (IBA)

4	Mitochondrial DNA (mtDNA)IBA 01/2022 - 03/2016
4	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 03/2014
4	LipidsIBA 11/2018 - 02/2010
3	AntibodiesIBA 01/2022 - 01/2019
3	Riboflavin (Vitamin B2)FDA LinkGeneric 01/2022 - 02/2010
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2013
3	Therapeutic UsesIBA 01/2022 - 03/2014
3	idebenoneIBA 01/2022 - 09/2015
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 03/2014
3	Transfer RNA (tRNA)IBA 01/2022 - 01/2020
3	AcidsIBA 01/2021 - 02/2010
3	fibroblast growth factor 21IBA 01/2020 - 07/2015
2	Lys Transfer RNAIBA 11/2022 - 11/2020
2	coenzyme Q10 (CoQ10)IBA 01/2022 - 01/2021
2	Staphylococcal Protein A (Protein A)IBA 01/2022 - 05/2021
2	oxidized low density lipoproteinIBA 12/2021 - 09/2015
2	Oxidoreductases (Dehydrogenase)IBA 05/2021 - 06/2013
2	Carnitine (L-Carnitine)FDA LinkGeneric 01/2021 - 11/2018
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2021 - 03/2014
2	Creatine Kinase (Creatine Phosphokinase)IBA 11/2020 - 12/2017
2	Growth Differentiation Factor 15IBA 01/2020 - 12/2017
2	Biomarkers (Surrogate Marker)IBA 12/2017 - 01/2017
2	Messenger RNA (mRNA)IBA 01/2017 - 07/2015
2	CateninsIBA 07/2016 - 09/2015
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/2015 - 06/2015
2	N-acylmannosamine kinaseIBA 01/2013 - 04/2011
2	Uridine Diphosphate (UDP)IBA 01/2013 - 04/2011
2	Racemases and Epimerases (Epimerases and Racemases)IBA 01/2013 - 04/2011
2	AcetylglucosamineIBA 01/2013 - 04/2011
1	Carrier Proteins (Binding Protein)IBA 10/2022
1	Carbamazepine (Tegretol)FDA LinkGeneric 10/2022
1	NucleotidesIBA 10/2022
1	Histidine (L-Histidine)FDA Link 10/2022
1	Retinaldehyde (Retinal)IBA 09/2022
1	ConnectinIBA 05/2022
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2022
1	Taurine FDA Link 01/2022
1	MorpholinosIBA 01/2022
1	SteroidsIBA 01/2022
1	Trp Transfer RNA (tRNA(Trp))IBA 01/2022
1	Metformin (Glucophage)FDA LinkGeneric 01/2022
1	BezafibrateIBA 01/2022
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2022
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2022
1	Immunoglobulin G (IgG)IBA 01/2022
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2022
1	DystrophinIBA 01/2022
1	ActininIBA 01/2022
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022
1	ApolipoproteinsIBA 12/2021
1	Apolipoproteins E (ApoE)IBA 12/2021
1	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 10/2021

Therapy/Procedure

8	Therapeutics 06/2022 - 01/2015
2	Denervation 01/2019 - 01/2016
1	Immunotherapy 01/2022
1	Vegetarian Diet (Vegetarianism) 01/2022